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. 2017 Jun 9;5:43. doi: 10.1186/s40478-017-0441-9

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Co-localization between SORL1 and APP in postmortem brain as detected by in situ PLA. a-c shows representative sections of the three groups; a Ctrl = controls, b sAD = sporadic AD, and c PED.25 = affected family member from PED.25. d The mean number of PLA dots/neuron, represented as horizontal bars (−), was quantified in pyramidal neurons in frontal cortex from controls (n = 4), sporadic AD (n = 4) and PED.25 (n = 2). A minimum of 100 neurons was quantified from every individual. The individual values are represented as filled squares (■)