Scheme 1. Synthesis of (±)-2. (i) THF/water, 4 (8 equivalents), EtN(iPr)2, 47%; see ref. 14a. (ii) THF, EtN(iPr)2, [5] and [6] ≤ 0.11 mM, 51%. (iii) TFA, DCM. (iv) NaOH, H2O, then Amberlyst 15 hydrogen form, then NaOH (to pH = 7).
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