Fig. 4.

Area under the receiver operating characteristic curve (AUC) derived from cross-validation studies by using three types of model (I–III) for the following adverse drug reactions (ADRs): rheumatic heart disease (Unified Medical Language System code C0035439), heat stroke (C0018843), spontaneous abortion (C0000786), and vestibular disorder (C0042594). These ADRs were correspondingly associated with 78, 331, 897, and 1022 drug pairs. For all panels, the horizontal axis represents the percentage of positive samples for an ADR used in the model training. The error bars show ±1 standard deviation from 50 simulations, using randomly selected training and test set samples