Table 2.
Drugs grouped by Anatomical Therapeutic Chemical (ATC) classification code and their relative distribution in clusters C1–C4 based on the similarity of their predicted adverse drug reactions induced by synergistic drug-drug interactions (ADRs)
| ATC code | Classification | All drugs | C1 % |
C2 % |
C3 % |
C4 % |
ADR | |
|---|---|---|---|---|---|---|---|---|
| N | % | |||||||
| A | Alimentary tract and metabolism | 64 | 10 | 12 | 14 | 10 | 8 | ~ |
| B | Blood and blood forming organs | 12 | 2 | 2 | 1 | 1 | 4 | ~ |
| C | Cardiovascular system | 88 | 14 | 22 | 24 | 11 | 8 | + + |
| D | Dermatologicals | 19 | 3 | 2 | 0 | 4 | 5 | – |
| G | Genito/urinary system and sex hormones | 28 | 5 | 0 | 4 | 6 | 7 | – |
| H | Systemic hormonal preparations | 9 | 1 | 0 | 1 | <1 | 4 | – |
| J | Anti-infectives for systemic use | 34 | 6 | 6 | 7 | 5 | 5 | ~ |
| L | Antineoplastic and immune-modulating agents | 61 | 10 | 1 | 1 | 11 | 20 | – – |
| M | Musculo-skeletal system | 45 | 7 | 16 | 7 | 4 | 5 | + + |
| N | Nervous system | 167 | 27 | 29 | 28 | 31 | 21 | ~ |
| P | Anti-parasitic products, insecticides, and repellents | 10 | 2 | 0 | 0 | 2 | 3 | – |
| R | Respiratory system | 49 | 8 | 6 | 11 | 8 | 7 | ~ |
| S | Sensory organs | 11 | 2 | 2 | 1 | 2 | 2 | ~ |
| V | Various | 16 | 3 | 3 | 2 | 3 | 2 | ~ |
Only drugs that have an ATC classification are included. The last column indicates the propensity of ADRs to be preferentially associated with compounds in clusters C1 and C2 (+ +), have no preferential association with drugs in any cluster (~), or be preferentially associated with compounds in clusters C3 and C4 (– or – –), respectively. Each column sums to 100% and the values indicate the distribution of drugs among the ATC classification for each cluster. The number of DDI-induced ADRs for each drug was highly variable, indicating no systematic variation of DDI-induced ADRs on a per drug basis among the ATC drug classes