Table 3.

Predicted distribution of different drug classes associated with four adverse drug reactions (ADRs)

ATC Classification		Spontaneous abortion			Vestibular disorder			Heat stroke			Rheumatic heart disease
		N	M	S	N	M	S	N	M	S	N	M	S
		(%)			(%)			(%)			(%)
A	Alimentary tract and metabolism	10	13	13	12	2	7	10	14	9	11	9	5
B	Blood and blood forming organs	2	0	2	2	0	0	3	0	0	2	0	0
C	Cardiovascular system	17	1	11	9	35	39	18	10	3	11	45	24
D	Dermatologicals	3	1	2	4	2	0	4	1	1	3	2	0
G	Genito/urinary system and sex hormones	4	11	0	5	3	5	6	4	1	5	0	0
H	Systemic hormonal preparations	2	0	0	2	2	0	2	0	0	2	2	0
J	Anti-infectives for systemic use	7	4	0	6	9	0	6	8	4	6	2	0
L	Antineoplastic and immune-modulating agents	12	0	2	12	5	0	15	0	0	10	9	5
M	Musculo-skeletal system	8	6	4	6	14	8	8	7	6	7	6	7
N	Nervous system	20	47	63	27	15	40	14	31	69	25	19	60
P	Anti-parasitic products, insecticides, and repellents	2	2	0	2	0	0	2	2	0	2	0	0
R	Respiratory system	7	15	4	9	8	0	6	18	6	9	0	0
S	Sensory organs	2	0	0	2	3	2	2	4	0	2	0	0
V	Various	3	0	0	3	3	0	4	0	1	2	6	0

We classified the drugs by two-way clustering of their DDI-induced ADR scores calculated from equation (3) into three categories: no ADR induction (category N), moderate ADR induction (category M), and strong ADR induction (category S). Fractions in categories M and S that are twice as large as the fraction in category N are indicated in bold. The columns sum to 100%, and the values characterize the distribution of drugs among the Anatomical Therapeutic Chemical (ATC) classifications for each cluster