Table 5.

Studies concerning the use of botulinum toxin type A (BoNT-A) in notalgia paresthetica

First author [Ref.], year	Type of study	n	BoNT-A doses	Retreatment	Follow-up	Results
Maari [72], 2014	RCT vs. placebo double-blind	20	max 200 U	No	12 weeks, then placebo arm shifted to BoNT-A; total 24 weeks	No significant difference for pruritus (VAS) and hyperpigmentation
Pèrez-Pèrez [73], 2014	Retrospective, case series	5	48 – 56 U	No	18 months	2 worsening pruritus, little improvement in other 3 but for only 1 month
Wallengren [71], 2010	Prospective	6	18 ' 100 U	No	18 months	5/6 patients a mean reduction of VAS by 28% at week 6; at 18 months 1 patient had a VAS of 45%, another one was still free from itch
Weinfeld [70], 2007	Case report	2	16 ' 24 U	Yes, 18 months later with 48 U (only 1 patient)	18 months	Improvement (patient self-assessment)

RCT, randomized clinical trial; VAS, Visual Analogue Scale.