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Replication of HCMV in SCID-hu thymus-liver implants. Concentrations of 2 × 105 PFU of AD169 (A), Toledo (T), ToledoBAC (B), ToledoΔ15kb (Δ), and ToledoΔ15kbR (R) were injected into thymus-liver implants in SCID mice. Thirteen days postinoculation, the tissues were collected and the titers in HFF cells were individually determined. The titer from each implant (filled triangle), the average titers (bars), and the number of mice in each experimental group (n) are indicated.
