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(A) Phylogenetic analysis of RNA sequences coding for helicase-ExoN (partial sequence). (B) Protein sequence alignment of coronavirus helicase-ExoN. The conserved motifs for helicases and the first motif for ExoN (DEDD motif I) are indicated. The invariant acidic residues in DEDD motif 1 are labeled with white stars below the sequences. The inverted open triangle above the sequences marks the predicted 3CL proteinase cleavage site.
