Table 4.
Baseline characteristics of trial subjects stratified into three genotypes of uncoupling protein 1 (UCP1)-3826A/G polymorphism in Japanese adults*
(Mean values with their standard errors)
| UCP1-3826A/G genotype… | A/A | A/G | G/G | ||||
|---|---|---|---|---|---|---|---|
| Mean | se | Mean | se | Mean | se | P | |
| Subjects | |||||||
| Number | 17 | 33 | 9 | 0·54 | |||
| Male % | 24 | 33 | 44 | ||||
| Age (years) | 55·1 | 3·2 | 54·7 | 2·2 | 57·1 | 3·7 | 0·88 |
| Weight (kg) | 66·0 | 3·9 | 66·6 | 2·1 | 68·2 | 4·0 | 0·86 |
| BMI (kg/m2) | 25·6 | 0·8 | 26·8 | 0·6 | 25·9 | 0·7 | 0·48 |
| Visceral fat area (cm2) | 88·6 | 8·8 | 112·2 | 10·8 | 129·2 | 13·5 | 0·14 |
| Resting energy expenditure (kcal/d)† | 1388 | 113 | 1340 | 57 | 1504 | 107 | 0·43 |
| Blood biochemistry | |||||||
| Glucose (mg/dl)† | 112 | 8 | 108 | 2 | 109 | 4 | 0·57 |
| HbA1c (%) | 5·4 | 0·3 | 5·2 | 0·1 | 5·4 | 0·2 | 0·29 |
| Insulin (μU/ml) | 7·1 | 0·9 | 9·0 | 0·7 | 8·6 | 1·4 | 0·18 |
| Total cholesterol (mg/dl)† | 209 | 10 | 211 | 7 | 191 | 13 | 0·39 |
| HDL-cholesterol (mg/dl)† | 58 | 3 | 58 | 2 | 57 | 3 | 0·92 |
| LDL-cholesterol (mg/dl)† | 120 | 10 | 123 | 5 | 111 | 14 | 0·46 |
| TAG (mg/dl)† | 142 | 20 | 152 | 29 | 127 | 25 | 0·83 |
| Aspartate aminotransferase (IU) | 20 | 2 | 21 | 1 | 28 | 4 | 0·08 |
| Alanine aminotransferase (IU) | 24 | 5 | 22 | 2 | 33 | 7 | 0·19 |
| γ-Glutamyl transpeptidase (IU) | 36 | 7 | 40 | 11 | 57 | 23 | 0·38 |
*
Subjects were stratified into three genotypes of UCP1. P values for comparison of parameters among the three genotypes were calculated using one-way ANOVA, Welch's test and a non-parametric Steel–Dwass test. No significant differences were found.
†
To convert kcal to kJ, multiply by 4·184; to convert glucose from mg/dl to mmol/l, multiply by 0·0555; to convert cholesterol from mg/dl to mmol/l, multiply by 0·0259; to convert TAG from mg/dl to mmol/l, multiply by 0·0113.