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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Curr Opin Behav Sci. 2016 Dec 3;13:117–123. doi: 10.1016/j.cobeha.2016.11.013

Figure 1. Time course of cocaine-induced increases in spine density in nucleus accumbens.

Figure 1

The percentage of studies reporting cocaine-induced spine changes over withdrawal gradually decreases from 100% at early time points (<1 day) to ~ 50% after 1 month. No studies report changes after 3 months of withdrawal. A table reporting the number of positive versus negative reports is given below.