FIG. 5.

Consequences of RNase L expression for reovirus-induced host shutoff. (A and B) wt (A) or RNase L KO (B) MEFs were mock infected or infected in triplicate with the indicated reovirus strains at an MOI of 80 PFU/cell. Levels of cellular translation were analyzed at 20 h p.i. as described in the legend to Fig. 2. (C) Graph depicting results from four separate experiments (Expt). The black bars represent the extent of cellular translation in wt MEFs; the grey bars represent that in RNase L KO MEFs. ND, not determined.