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. 2017 May 15;114(22):E4511–E4519. doi: 10.1073/pnas.1705233114

Fig. 5.

Fig. 5.

SlDML2-mediated DNA demethylation correlates with ripening-induced gene activation, as well as with ripening-induced gene repression. (A) The k-means clustering of sldml2-1 hyper-DMR–associated gene expression. Genes associated with sldml2-1 (46 dpa) hyper-DMRs were subjected to the clustering analysis. (B) DNA methylation changes in cluster 1 and cluster 2 genes in sldml2-1-46dpa vs. WT-46dpa. The sequences flanking cluster 1 and 2 genes were aligned, and DNA methylation levels for each 100-bp interval were plotted. The dashed line marks transcription start sites. (C) DNA methylation changes in cluster 1 and cluster 2 genes in ripe fruits compared with immature fruits. (Upper) DNA methylation differences between WT-46dpa and WT-25dpa. (Lower) DNA methylation differences between AC-52dpa and AC-17dpa.