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. 2017 May 15;114(22):5719–5724. doi: 10.1073/pnas.1701736114

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Fig. S7. — Effects of amphetamine on tissue levels of dopamine and DOPAC in ST mice (related to Figs. 2–4). (A) A main effect of amphetamine is observed in a two-way ANOVA of amphetamine’s effect on dopamine levels in the SN of WT and ST mice [two-way ANOVA; drug × genotype F(1,23) = 0.05, P = 0.83; drug F(1,23) = 7.95, P < 0.01; genotype F(1,23) = 3.29, P = 0.08. n = 7 per genotype for each treatment]. (B) A main effect of amphetamine and genotype is observed in a two-way ANOVA of amphetamine’s effect on DOPAC levels in the SN of WT and ST mice [two-way ANOVA; drug × genotype, F(1,23) = 0.78, P = 0.39; drug F(1,23) = 13.54, P < 0.01; genotype F(1,23) = 4.35, P < 0.05. n = 7 per genotype for each treatment]. (C) Neither amphetamine nor genotype had a significant effect on tissue levels of dopamine in the VTA [two-way ANOVA; drug × genotype F(1,23) = 0.99, P = 0.33; genotype F(1,23) = 0.1294, P = 0.72, n = 7 per genotype for each treatment]. (D) A main effect of amphetamine is observed in a two-way ANOVA of amphetamine’s effect on DOPAC levels in the VTA of WT and ST mice [two-way ANOVA; drug × genotype F(1,23) < 0.0001, P = 0.99; drug F(1,23) = 10.3, P < 0.01, n = 7 per genotype for each treatment]. (E) A main effect of amphetamine is observed in a two-way ANOVA of amphetamine’s effect on dopamine levels in the dorsal striatum (DS) of WT and ST mice [two-way ANOVA; drug × genotype F(1,24) = 1.13, P = 0.30; drug F(1,24) = 6.8, P = 0.01; genotype F(1,24) = 3.92, P = 0.06; n = 7 per genotype for each treatment]. (F) Neither amphetamine nor genotype had a significant effect on dorsal striatum DOPAC levels [two-way ANOVA; drug × genotype F(1,24 ) = 0.01, P = 0.92; genotype F(1,24) = 0.11, P = 0.74, n = 7 per genotype for each treatment]. (G) Neither amphetamine nor genotype had a significant effect on NAc dopamine tissue levels [two-way ANOVA; drug × genotype F(1,24) = 0.2, P = 0.65; drug F(1.24) = 3.43, P = 0.08; genotype F(1,23) = 0.51, P = 0.48, n = 7 per genotype for each treatment]. (H) Neither amphetamine nor genotype had a significant effect on NAc DOPAC tissue levels [two-way ANOVA; drug × genotype F(1,24) = 0.03, P = 0.87; genotype F(1,24) = 0.11, P = 0.75, n = 7 per genotype for each treatment].