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. 2005 Feb;79(4):2346–2355. doi: 10.1128/JVI.79.4.2346-2355.2005

FIG. 8.

FIG. 8.

Summary of selected NS5A domains and interaction sites. The locations of Gly404 and Glu442, which were mutated in the RBV-resistant replicons, are indicated by black circles. The 447-amino-acid sequence of NS5A is drawn schematically to scale. PP1 and PP2, polyproline motifs 1 and 2; ISDR, interferon-sensitivity determining region; NLS, nuclear localization sequence; V3, variable region 3. See the following references for more information: phosphorylation sites (25, 51), NLS (23), ISDR (12, 13), V3 (34), PP1 and PP2 (50), karyopherins β3 (7), PKR (15), NS5B (44), hVAP-A (14), La (22), 2′-5′ OAS (2′-5′ oligoadenylate synthetase) (48), HCV core (19), HSP27 (6), p85 (regulatory subunit of phosphatidylinositol 3-kinase) (45), TRAF2 (35), ApoAI (42), PTX1 (17), p53 and hTAFII (26), Grb2 (29, 50), Lyn/Hck/Fyn/Lck (29), amphiphysinII (55), green fluorescent protein insertion sites (33), and region deleted in HeLa-adapted replicon (57).