Table S1.

Mutation rate analysis (URA3 inactivation) for several mutant strains

	Mutation rate (fold increase)* 5-FOAR
Relevant genotype	wt-POL	pol1-L868M	pol2-M644G	pol3-L612M
WT	9.5 [8.0–14.0] × 10−8 (1)	4.8 [3.6–6.7] × 10−7 (5)	1.4 [1.0–2.4] × 10−6 (15)	6.6 [5.2–10.8] × 10−7 (7)
gln3Δ	nd	1.9 [1.3–2.2] × 10−5 (199)	2.5 [1.3–3.9] × 10−6 (26)	6.3 [4.1–15.1] × 10−6 (66)
ura7Δ	nd	1.1 [0.8–1.3] × 10−5 (111)	2.1 [1.8–3.2] × 10−6 (22)	1.8 [0.7–3.8] × 10−5 (192)

Relates to Tables 1 and 2.

^*Median rates of URA3 inactivation (5-FOA^R) with 95% confidence interval in square brackets and fold increase relative to the WT in parentheses. “nd” indicates not determined.