Table S5.
dNTP concentrations for several mutants
| Relevant genotype | dCTP | dTTP | dATP | dGTP |
| WT | 75 ± 4 (1.0) | 159 ± 14 (1.0) | 102 ± 3 (1.0) | 59 ± 0 (1.0) |
| pol1-L868M | 70 ± 1 (0.9) | 214 ± 11 (1.3) | 114 ± 1 (1.1) | 63 ± 3 (1.1) |
| pol2-M644G | 292 ± 20 (3.9) | 629 ± 37 (4.0) | 450 ± 20 (4.4) | 205 ± 9 (3.5) |
| pol3-L612M | 85 ± 25 (1.1) | 149 ± 12 (0.9) | 91 ± 4 (0.9) | 54 ± 2 (0.9) |
| gln3Δ | 43 ± 3 (0.6) | 641 ± 76 (4.0) | 293 ± 20 (2.9) | 141 ± 6 (2.4) |
| shm2Δ | 75 ± 2 (1.0) | 178 ± 18 (1.1) | 115 ± 12 (1.1) | 62 ± 3 (1.1) |
| ura7Δ | 35 ± 6 (0.5) | 517 ± 17 (3.3) | 386 ± 3 (3.8) | 158 ± 7 (2.7) |
| dun1Δ gln3Δ* | 27 ± 3 (0.4) | 134 ± 65 (0.8) | 71 ± 34 (0.7) | 47 ± 20 (0.8) |
| dun1Δ ura7Δ* | 27 ± 14 (0.4) | 134 ± 2 (0.8) | 98 ± 2 (1.0) | 42 ± 5 (0.7) |
Relates to Fig. 4. dNTP concentrations (in picomoles per 108 cells) are the average of two biological replicates ± SD with the fold increase over WT in parentheses.
*
dNTP concentrations were measured at a different time point and normalized according to a WT strain included in the same run.