Table 2.

Mutation rate analysis of the mutants identified in this screen in combination with alleles causing reduced DNA replication fidelity

	Mutation rate (fold increase)* CanR
Relevant genotype	WT	exo1Δ	msh6Δ	pol2-04
WT	7.2 [5.7–9.0] × 10−8 (1)	7.4 [6.3–9.8] × 10−7 (10)	9.6 [7.8–11.7] × 10−7 (13)	6.2 [4.3–7.6] × 10−7 (6)
gln3Δ	1.0 [0.8–1.2] × 10−7 (1)	1.1 [0.8–1.4] × 10−5 (146)	2.4 [1.7–3.4] × 10−5 (334)	1.1 [0.9–1.6] × 10−5 (154)
shm2Δ	1.2 [0.8–2.8] × 10−7 (2)	8.4 [7.1–10.5] × 10−7 (12)	2.1 [1.3–2.6] × 10−6 (30)	1.5 [1.1–2.3] × 10−6 (22)
ura7Δ	1.0 [0.9–1.5] × 10−7 (1)	1.9 [0.8–2.4] × 10−5 (261)	3.8 [3.2–8.5] × 10−5 (524)	2.5 [1.8–5.2] × 10−5 (354)
rrm3Δ	1.1 [0.8–1.5] × 10−7 (2)	6.3 [4.3–7.6] × 10−7 (9)	4.9 [3.6–7.3] × 10−6 (68)	1.4 [0.9–1.8] × 10−6 (19)

^*Median rates of inactivation of CAN1 gene (Can^R) with 95% confidence interval in square brackets and fold increase relative to the WT in parentheses.