Fig. 4.

XAF1–MT2A antagonism regulates cellular response to metal stress. (A and B) IB assays showing opposite responses of XAF1 and MT2A to cytostatic and cytotoxic metal stresses. (C) A crucial role for XAF1–MT2A mutual antagonism in cellular response to metal stress. Cells were treated with indicated doses of CdCl₂ for 24 h. (D) Enhancement of metal-induced apoptosis by WT-XAF1. (E) XAF1-mediated apoptotic switch of cellular response to cytostatic metal stress and MT2A attenuation of apoptotic response to cytotoxic metal stress.