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Structural comparisons within the EHD family. (A) A superposition of the EHD4ΔN ATPγS and ADP-bound structures. Only minor changes in the GTPase domains were apparent (Right). Note that in the ADP-bound EHD4 structure, switch I is disordered. (B) A superposition of EHD2 and EHD4 GTPase domain dimers indicates an almost identical architecture. (C) Interaction details in the GTPase domain dimerization interface of EHD4ΔN.
