Skip to main content
. 2017 May 15;114(22):5731–5736. doi: 10.1073/pnas.1700499114

Fig. 4.

Fig. 4.

Effects of repeated YNT-185 administration on SOREMs and body weights in OXKO mice. (A) Effect of repeated once-a-day administration on SOREMs in OXKO mice (n = 5). (B) Effect of repeated administration every 3 h during the dark period for 3 consecutive nights on SOREMs in OXKO mice (n = 6). (B, Left) Number of SOREMs in each 3-h period during the dark phase, averaged over the 3 nights. (B, Right) Total number of SOREMs through 12-h dark periods for 3 consecutive nights. (C) Daily i.p. administration of YNT-185 decreased the body weight in aged OXKO mice. (C, Left) There were no difference in body weight between vehicle- and YNT-185–administered aged OXKO mice (24 wk old) before administration (n = 8). (C, Center) Increase in body weight in aged OXKO mice (24 wk old) was significantly suppressed by daily i.p. administration of YNT-185 immediately before dark period for 14 d. (C, Right) After stopping administration of YNT-185, the body weight increased in aged OXKO mice. *P < 0.05,‡P < 0.005. n.s., not significant.