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. 2017 May 15;114(22):5731–5736. doi: 10.1073/pnas.1700499114

Fig. S3.

Fig. S3.

I.p.-administered YNT-185 at ZT6 suppress sleep and has no effect on sleep/wake states of wild-type mice in the remaining light period and the subsequent dark period. (A) Amounts of time spent in NREM within 3 h after the i.p. administrations at ZT6 in wild-type mice (n = 6). (B) Amounts of time spent in REM within 3 h after the i.p. administrations at ZT6 in wild-type mice (n = 6). (C) Amounts of time spent in NREM within 3 h after the i.p. administrations at ZT6 in OXRDKO mice (n = 5). (D) Amounts of time spent in REM within 3 h after the i.p. administrations at ZT6 in OXRDKO mice (n = 5). (E) Hourly plots of wake time. Total time (F), episode duration (G), episode number (H) of sleep/wake states in the subsequent dark period after the i.p. administration at ZT6 in wild-type mice (n = 6). *P < 0.05. n.s., not significant.