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. 2017 May 15;114(22):E4472–E4481. doi: 10.1073/pnas.1702302114

Fig. S7.

Fig. S7.

Examples of metabolites that statistically associate with LG, HGxoLG, or HG diets and pathway analysis of metabolites that associated with the retinal damage score. (A) Boxplots show the distribution of metabolites from the plasma metabolome (Left) or the urine metabolome (Right) that have diet-only associations with the LG diet (Top), the HGxoLG diet (Middle), or the HG diet (Bottom). Full lists of diet-associated metabolites are given in Tables S2 and S5. (B) Chart showing metabolites associated with the retinal damage score from the urine dataset (Top, blue), from the plasma dataset (Bottom, red), or from both (purple) and the metabolic pathways to which they contribute. Only pathways that involve two or more metabolites are listed, and only metabolites that associate with at least one annotated pathway are listed. Statistics: *P < 0.05; **P < 0.01; #P < 0.001. The sample size in A, Left was n = 11 (LG), n = 10 (HGxoLG), n = 11 (HG); the sample size in A, Right was n = 4 (LG), n = 5 (HGxoLG), n = 4 (HG).