Table 2.
Associations of geometric mean maternal urinary BPA and phthalate concentrations across pregnancy (“in utero” exposure) with offspring serum lipid levels at 8–14 years among ELEMENT mother-child pairs (n = 227).
| Maternal urinary concentrationsc | Mean ± SDa | % Difference (95% CI) in serum lipid levels during peripuberty per IQR in maternal urinary BPA and phthalate concentrationsb | |||
|---|---|---|---|---|---|
| Total Cholesterol | LDL-C | HDL-Cc | Triglyceridesc | ||
|
|
|||||
| BPA | 1.1 ± 1.0 ng/mL | −2.0 (−5.7, 1.8) | −4.0 (−10.0, 2.0) | −1.0 (−5.2, 3.4) | 0.4 (−8.8, 10.6) |
| MBzP | 4.7 ± 4.7 ng/mL | −1.8 (−5.2, 1.7) | −2.4 (−7.9, 3.2) | −0.9 (−4.8, 3.1) | −2.7 (−10.9, 6.3) |
| MCPP | 1.5 ± 1.2 ng/mL | 0.7 (−3.2, 4.7) | 1.4 (−5.0, 7.9) | −1.1 (−5.6, 3.6) | 2.7 (−7.3, 13.7) |
| MEP | 245 ± 370 ng/mL | −1.5 (−5.4, 2.4) | 0 (−6.3, 6.3) | −4.0 (−8.3, 0.4) | 0.8 (−8.8, 11.5) |
| ΣDEHP | 0.3 ± 0.3 nmol/mL | −1.2 (−4.9, 2.4) | −2.1 (−8.0, 3.8) | −2.0 (−6.1, 2.3) | 2.6 (−6.6, 12.7) |
| ΣDBP | 0.4 ± 0.4 nmol/mL | 0.1 (−3.6, 3.7) | 1.4 (−4.5, 7.3) | −1.7 (−5.8, 2.5) | 0.5 (−8.5, 10.4) |
a
Values are not corrected for dilution.
b
Estimates are adjusted for child’s age at the time of lipid assessment, sex, and urinary specific gravity.
c
Natural-log (ln) transformed for analysis