Table 3.
Sex-specific associations of concurrent urinary concentrations of BPA and phthalate metabolites with serum lipid levels at 8–14 years among ELEMENT youth.
| Concurrent urinary concentrationsc | Mean ± SDa | % Difference (95% CI) in serum lipids during peripuberty per IQR increment in urinary BPA and phthalate concentrationsb | |||
|---|---|---|---|---|---|
| Total Cholesterol | LDL-C | HDL-Cc | Triglyceridesc | ||
|
|
|
||||
| Boys (n = 112) | |||||
| BPA | 2.0 ± 4.2 ng/mL | −0.7 (−5.8, 4.3) | −4.6 (−12.9, 3.8) | 3.4 (−2.4, 9.5) | −0.7 (−12.9, 13.2) |
| MBzP | 7.4 ± 5.9 ng/mL | −0.7 (−6.3, 4.4) | −7.2 (−16.3, 2.0) | 6.6 (0.2, 13.5) | 0.8 (−12.8, 16.4) |
| MCPP | 2.7 ± 2.6 ng/mL | −7.4 (−12.8, −2.0) | −12.7 (−21.6, −3.8) | −0.8 (−6.9, 5.7) | −7.2 (−19.6, 7.1) |
| MEP | 173 ± 354 ng/mL | −5.7 (−10.4, −1.0) | −10.8 (−18.5, −3.1) | 1.0 (−4.4, 6.7) | −2.9 (−14.2, 10.0) |
| ΣDEHP | 1.7 ± 11.0 nmol/mL | −0.5 (−4.6, 3.7) | −1.3 (−8.1, 5.5) | 2.1 (−2.6, 6.9) | −5.3 (−14.8, 5.3) |
| ΣDBP | 0.7 ± 0.7 nmol/mL | −6.7 (−11.8, −1.6) | −9.9 (−18.4, −1.5) | −5.2 (−10.6, 0.6) | −1.9 (−14.4, 12.3) |
| Girls (n = 128) | |||||
| BPA | 2.0 ± 2.6 ng/mL | 0.1 (−4.5, 4.7) | −0.2 (−7.4, 7.1) | −1.9 (−7.3, 3.8) | 8.8 (−3.5, 22.6) |
| MBzP | 9.5 ± 16.7 ng/mL | −0.8 (−5.4, 3.9) | −0.5 (−7.9, 6.9) | −1.0 (−6.6, 4.9) | 2.4 (−9.4, 15.8) |
| MCPP | 4.7 ± 13.1 ng/mL | −1.4 (−5.2, 2.4) | −4.3 (−10.2, 1.7) | 1.2 (−3.5, 6.0) | 2.1 (−7.6, 12.9) |
| MEP | 335 ± 797 ng/mL | −1.7 (−5.5, 2.2) | 4.5 (−10.5, 1.5) | 1.4 (−3.3, 6.4) | 0.8 (−8.9, 11.6) |
| ΣDEHP | 0.6 ± 0.6 nmol/mL | −4.3 (−9.1, 0.5) | −7.9 (−15.4, −0.4) | −3.5 (−9.1, 2.4) | 4.5 (−8.0, 18.7) |
| ΣDBP | 1.1 ± 2.8 nmol/mL | −1.4 (−5.4, 2.7) | −5.9 (−12.3, 0.5) | 4.3 (−0.8, 9.7) | 1.0 (−9.3, 12.4) |
a
Values are not corrected for dilution.
b
Estimates are adjusted for child’s age at the time of lipid assessment and urinary specific gravity.
c
Natural-log (ln) transformed.