TABLE 1.

AP-binding motifs

Sequence	Previously described characteristicsa
GENTSLL	Wild-type sequence of NefNL4-3, the LL is required for Nef-mediated down-regulation of CD4 and optimal viral infectivity
EERQPLL	From the melanosomal protein tyrosinase, binds selectively to intact AP-3 in vitro, EE and LL sequences required for binding
GDKQTLL	From the TCR γ chain, binds intact AP-1 and AP-2 in vitro, causes lysosomal targeting
DERAPLI	From LIMP II, binds intact AP-1 and AP-3 in vitro, DE sequence required for binding to AP-3
GAGYQTI	From the lysosomal glycoprotein 120 (LAMP I), binds preferentially to the μ subunit of AP-3 in yeast two-hybrid assays
GSDYQRL	From the TGN38 protein, binds to the μ subunits of AP-1, -2, and -3 in yeast two-hybrid assays

^aReferenced in the text.