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. Author manuscript; available in PMC: 2018 Jan 11.
Published in final edited form as: J Am Chem Soc. 2016 Dec 22;139(1):409–416. doi: 10.1021/jacs.6b11087

Figure 4.

Figure 4

(A) Synthesis of G-Paro (G-Kana followed analogous procedures): (a) 1,3-di-Boc-2-(trifluoromethylsulfonyl)guanidine, triethylamine, 5:1 dioxane:water, rt, 3 days; (b) HCl, ethyl acetate, rt, 4 h. (B) PCA plot of RNA training set with expanded aminoglycoside receptor library. A total of nine commercially available aminoglycosides and 2 guanidino-aminoglycosides were used as receptors. Ovals indicate 95% confidence intervals for each cluster.