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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: J Invest Dermatol. 2016 Oct 26;137(3):576–586. doi: 10.1016/j.jid.2016.09.033

Figure 2. Topical JP4-039 prevents skin damage from radiation induced oxidative stress.

Figure 2

Mice were irradiated with 35 Gy and left untreated or treated topically with JP4-039 or formulation alone 0.5, 24 and 48 h after irradiation. Shown are representative clinical photographs 21 days post-irradiation are shown (a), skin barrier function determined with TEWL (b), differences between extension of irradiated and non-irradiated legs (c) and collagen fibers (d) (bar = 80μm). Representative H&E stained sections are provided in (e) with arrows delineating dermal and epidermal thickness (bar = 40μm). Dermal (f) 100X) and epidermal (g) thickness (200X) were measured. Infiltrating cells in 400X sections were counted (h). All data are presented as mean ± SEM (n=10–20). Statistical significance was determined by ANOVA followed by a Bonferroni post-test set at p<0.05.