Mice bearing palpable MOC1 tumors were treated with 15 mg/kg IPI-145 (daily × 14 days) and PD-L1 mAb (200 μg/injection × 3) alone or in combination and mice were followed for tumor growth and survival (n=8–10 mice/group). A, primary tumor growth summary curves during treatment and in the immediate post-treatment period (Tukey’s multiple comparisons analysis). B, survival analysis. C, individual growth curves (in color) compared to control (black) demonstrating long-term growth kinetics for each experimental condition. IPI-145 treatment indicated below x-axis, black arrows indicate PD-L1 mAb treatments. *, p<0.05; **, p<0.01; ***, p<0.001.