Table 5.
Regions of interest (ROIs) by neuropathology type associated with gait in reviewed papers
| ROI | WM | GM | Neuronal activity | Aβ | Tau | Total |
|---|---|---|---|---|---|---|
| Frontal lobe | xxx | xxxxxxx | xx | 12 | ||
| Parietal lobe | xxxxx | xx | x | 8 | ||
| Temporal lobe | x | xxxx | x | x | 7 | |
| Cerebellum | xxxx | xx | 6 | |||
| Cingulate | xx | xx | x | 5 | ||
| Motor cortex | xx | xxx | 5 | |||
| Somatosensory cortex | xxx | xx | 5 | |||
| Hippocampus | xxx | x | 4 | |||
| Occipital lobe | x | xx | x | 4 | ||
| Caudate | x | x | 2 | |||
| Corpus callosum | xxx | 3 | ||||
| Insula | xxx | 3 | ||||
| Putamen | xx | x | 3 | |||
| Fusiform gyrus | x | x | 2 | |||
| Parahippocampal gyrus | x | x | 2 | |||
| Precuneus | x | x | 2 | |||
| Thalamus | x | x | 2 | |||
| Cingulum | x | 1 | ||||
| Corona radiata | x | 1 | ||||
| Lingual gyrus | x | 1 | ||||
| Pallidum | x | 1 | ||||
| Substantia nigra | x | 1 | ||||
|
| ||||||
| Total by pathology type | 17 | 41 | 18 | 7 | 2 | |
WM, white matter; GM, grey matter, Aβ, amyloid beta protein
It should be noted that Buchman and colleagues (2008; 2013) [66, 67] investigated the association between AD pathology (neuritic plaques, diffuse plaques, and neurofibrillary tangles) averaged across midfrontal, superiortemporal, inferior parietal, entorhinal, and hippocampal ROIs and gait, so it was not possible to differentiate by ROI or pathology type in these instances.