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Effects of i.t. injection of ZD7288 (30 µg) on behavioral mechanical allodynia (a), thermal hyperalgesia (b), and spontaneous pain (c) in CRP rats. Note that mechanical allodynia and spontaneous pain were largely alleviated by ZD7288, while thermal hyperalgesia was not (n = 6 for each group). All data are expressed as mean ± SEM. *P < 0.05 as compared to basal state, #P < 0.05 as compared to prestate (before ZD7288).
