Table 2.

HRs (95% CIs) of incident stroke according to types of stroke and family history status

Group	Family history status	No. of subjects	Incident strokes	Person-years	Incidence rate (per 1,000 person years)	Model 1*		Model 2†
						HR (95% CI)	Ptrend§	HR (95% CI)	Ptrend§
Total stroke‡	No	387,864	19,988	2,734,939	7.31	1.00		1.00
	Yes	85,985	6,407	603,322	10.62	1.50 (1.46–1.55)		1.34 (1.31–1.38)
	1 member	74,931	5,158	527,282	9.78	1.41 (1.37–1.46)		1.28 (1.24–1.32)
	2 members	9,796	1,044	67,602	15.44	1.98 (1.86–2.11)		1.66 (1.56–1.77)
	≥3 members	1,258	205	8,439	24.29	2.47 (2.15–2.84)	<0.001	1.93 (1.68–2.21)	<0.001
Hemorrhagic stroke
	No	371,787	3,911	2,663,576	1.47	1.00		1.00
	Yes	80,635	1,057	579,429	1.82	1.28 (1.20–1.37)		1.24 (1.16–1.33)
	1 member	70,634	861	508,128	1.69	1.21 (1.13–1.31)		1.18 (1.10–1.28)
	2 members	8,916	164	63,617	2.58	1.64 (1.41–1.92)		1.53 (1.31–1.79)
	≥3 members	1,085	32	7,683	4.17	2.11 (1.49–2.99)	<0.001	1.89 (1.33–2.67)	<0.001
Ischemic stroke
	No	383,225	15,349	2,716,424	5.65	1.00		1.00
	Yes	84,757	5,179	598,374	8.66	1.59 (1.54–1.64)		1.39 (1.34–1.43)
	1 member	73,930	4,157	523,235	7.94	1.48 (1.43–1.54)		1.32 (1.27–1.36)
	2 members	9,604	852	66,854	12.74	2.11 (1.97–2.26)		1.72 (1.60–1.84)
	≥3 members	1,223	170	8,285	20.52	2.69 (2.31–3.13)	<0.001	2.01 (1.73–2.34)	<0.001

HR, hazard ratio; CI, confidence interval.

^*Model 1: adjusted for age and sex.

^†Model 2: Model 1 plus adjustment for marital status, education, residential area, smoking status, alcohol consumption, physical activity, body mass index, history of hypertension, history of diabetes and siblings.

^‡Including hemorrhagic stroke, ischemic stroke and stroke of unknown type.

^§P_trend: Linear trend test P-value for HRs’ across number of members having stroke history for each stroke type within each model.