Table 1. List of proteins associated to at least two diseases.
The complete list of all disease-associated proteins can be found at S8 Table. Number of proteins associated to asthma and eczema: 16; to asthma and rhinitis: 35; to eczema and rhinitis: 5. To all three diseases: 5.
| Protein name (UniProt accession) | gene name (HGNC) | protein name | location | asthma | eczema | rhinitis |
|---|---|---|---|---|---|---|
| P05112 | IL4 | interleukin 4 | 5q31.1 | √ | √ | √ |
| P35225 | IL13 | interleukin 13 | 5q31.1 | √ | √ | √ |
| Q01638 | IL1RL1 | interleukin 1 receptor-like 1 | 2q12.1 | √ | √ | √ |
| Q13478 | IL18R1 | interleukin 18 receptor 1 | 2q12.1 | √ | √ | √ |
| Q969D9 | TSLP | thymic stromal lymphopoietin | 5q22.1 | √ | √ | √ |
| O95760 | IL33 | interleukin 33 | 9p24.1 | √ | √ | |
| P01584 | IL1B | interleukin 1 beta | 2q14.1 | √ | √ | |
| P05113 | IL5 | interleukin 5 | 5q31.1 | √ | √ | |
| P13501 | CCL5 | chemokine (C-C motif) ligand 5 | 17q12 | √ | √ | |
| P40425 | PBX2 | pre-B-cell leukemia homeobox 2 | 6p21.32 | √ | √ | |
| P51671 | CCL11 | chemokine (C-C motif) ligand 11 | 17q12 | √ | √ | |
| P51677 | CCR3 | chemokine (C-C motif) receptor 3 | 3p21.31 | √ | √ | |
| Q8IZI9 | IFNL3 | interferon, lambda 3 | 19q13.2 | √ | √ | |
| Q99466 | NOTCH4 | notch 4 | 6p21.32 | √ | √ | |
| Q9Y496 | KIF3A | kinesin family member 3A | 5q31.1 | √ | √ | |
| Q9Y4H4 | GPSM3 | G-protein signaling modulator 3 | 6p21.32 | √ | √ | |
| P01303 | NPY | neuropeptide Y | 7p15.3 | √ | √ | |
| P01906 | HLA-DQA2 | major histocompatibility complex, class II, DQ alpha 2 | 6p21.32 | √ | √ | |
| P01909 | HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | 6p21.32 | √ | √ | |
| P01912 | HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 | 6p21.32 | √ | √ | |
| P01920 | HLA-DQB1 | major histocompatibility complex, class II, DQ beta 1 | 6p21.32 | √ | √ | |
| P13760 | HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 | 6p21.32 | √ | √ | |
| P13761 | HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 | 6p21.32 | √ | √ | |
| P16109 | SELP | selectin P | 1q24.2 | √ | √ | |
| P20039 | HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 | 6p21.32 | √ | √ | |
| P21731 | TBXA2R | thromboxane A2 receptor | 19p13.3 | √ | √ | |
| P24394 | IL4R | interleukin 4 receptor | 16p12.1 | √ | √ | |
| P50135 | HNMT | histamine N-methyltransferase | 2q22.1 | √ | √ | |
| P84022 | SMAD3 | SMAD family member 3 | 15q22.33 | √ | √ | |
| Q13093 | PLA2G7 | phospholipase A2 group VII | 6p12.3 | √ | √ | |
| Q15399 | TLR1 | toll-like receptor 1 | 4p14 | √ | √ | |
| Q30134 | HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 | 6p21.32 | √ | √ | |
| Q30167 | HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 | 6p21.32 | √ | √ | |
| Q5Y7A7 | HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 | 6p21.32 | √ | √ | |
| Q8NI36 | WDR36 | WD repeat domain 36 | 5q22.1 | √ | √ | |
| Q95IE3 | HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 | 6p21.32 | √ | √ | |
| Q96D42 | HAVCR1 | hepatitis A virus cellular receptor 1 | 5q33.3 | √ | √ | |
| Q96QA5 | GSDMA | gasdermin A | 17q21.1 | √ | √ | |
| Q9GIY3 | HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 | 6p21.32 | √ | √ | |
| Q9HBE5 | IL21R | interleukin 21 receptor | 16p12.1 | √ | √ | |
| Q9HBL0 | TNS1 | tensin 1 | 2q35 | √ | √ | |
| Q9NQ38 | SPINK5 | serine peptidase inhibitor, Kazal type 5 | 5q32 | √ | √ | |
| Q9TQE0 | HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 | 6p21.32 | √ | √ | |
| Q9UIL8 | PHF11 | PHD finger protein 11 | 13q14.2 | √ | √ | |
| Q9UKT9 | IKZF3 | IKAROS family zinc finger 3 | 17q21.1 | √ | √ | |
| Q9UKW4 | VAV3 | vav guanine nucleotide exchange factor 3 | 1p13.3 | √ | √ |