Table 2. Functional similarity between asthma, eczema and rhinitis.
Numerical values show how similar is the use of a cellular pathway by pairs of trios of diseases. Similarity = 1 means that the diseases affect the pathway in exactly the same way. Similarity = 0 is represented by blank cells. Two asterisks: similarity is significantly larger than random expectation (z-test; P < 0.01). One asterisk: similarity is significantly larger than random expectation (z-test; P < 0.05). All significant similarities were also significantly larger than observed for pairs and trios of immune system diseases (empirical distribution test; P < 0.01).
| Cellular pathway | Overlap score for: | |||
|---|---|---|---|---|
| asthma and eczema | asthma and rhinitis | eczema and rhinitis | asthma, eczema and rhinitis | |
| Regulation of hematopoiesis by cytokines | 1.00 ** | |||
| CCR3 signaling in Eosinophils | 1.00 ** | |||
| The Role of Eosinophils in the Chemokine Network of Allergy | 0.57 ** | 0.14 | ||
| IL 4 signaling pathway | 0.53 ** | 1.00 ** | 0.53 ** | 0.53 ** |
| GATA3 participate in activating the Th2 cytokine genes expression | 1.00 ** | 0.67 * | 0.67 ** | 0.67 ** |
| Cytokine Network | 0.50 * | 0.33 | 0.50 ** | 0.30 ** |
| IL12 and Stat4 Dependent Signaling Pathway in Th1 Development | 0.28 | 0.40 | 0.33 ** | 0.23 ** |
| Th1/Th2 Differentiation | 0.25 | 0.48 | 0.42 ** | 0.23 * |
| Erythrocyte Differentiation Pathway | 0.50 * | |||
| The 4-1BB-dependent immune response | 0.22 | 1.00 * | 0.22 ** | 0.22 ** |
| Dendritic cells in regulating TH1 and TH2 Development | 0.56 ** | 0.25 | 0.33 ** | 0.22 * |
| Role of Tob in T-cell activation | 0.07 | 0.57 | 0.13 | 0.07 |
| Antigen Dependent B Cell Activation | 0.06 | 0.31 | 0.20 ** | 0.06 |
| Cytokines and Inflammatory Response | 0.23 | 0.24 | 0.25 * | 0.10 |
| IL2 Receptor Beta Chain in T cell Activation | 0.03 | 0.27 | 0.04 | 0.02 |
| Selective expression of chemokine receptors during T-cell polarization | 0.41 | 0.58 | 0.37 ** | 0.30 ** |
| IL 5 Signaling Pathway | 0.30 | 0.30 | 0.20 * | 0.10 |
| NFkB activation by Nontypeable Hemophilus influenzae | 0.25 | 0.25 | ||
| TGF beta signaling pathway | 0.58 | |||
| Adhesion and Diapedesis of Granulocytes | 0.11 | 0.33 | ||
| Cell Cycle: G1/S Check Point | 0.42 | |||
| Monocyte and its Surface Molecules | 0.40 | |||
| Antigen Processing and Presentation | 0.33 | |||
| Cells and Molecules involved in local acute inflammatory response | 0.29 | |||
| Bystander B Cell Activation | 0.27 | |||
| Activation of Csk by cAMP-dependent Protein Kinase Inhibits. . . | 0.26 | |||
| Lck and Fyn tyrosine kinases in initiation of TCR Activation | 0.26 | |||
| The Co-Stimulatory Signal During T-cell Activation | 0.26 | |||
| Signal transduction through IL1R | 0.25 | |||
| B Lymphocyte Cell Surface Molecules | 0.23 | |||
| IL10 Anti-inflammatory Signaling Pathway | 0.10 | |||
| Cystic Fibrosis Transmembrane Conductance Regulator And Beta 2. . . | 0.08 | |||
| Pertussis toxin-insensitive CCR5 Signaling in Macrophage | 0.07 | |||
| Role of ERBB2 in Signal Transduction and Oncology | 0.05 | |||
| IL 6 signaling pathway | 0.05 | |||
| Ceramide Signaling Pathway | 0.04 | |||
| NO2-dependent IL 12 Pathway in NK cells | 0.04 | |||
| NFAT and Hypertrophy of the heart (Transcription in the broken heart) | 0.04 | |||
| Signaling of Hepatocyte Growth Factor Receptor | 0.03 | |||
| TNFR1 Signaling Pathway | 0.03 | |||
| HIV-I Nef: negative effector of Fas and TNF | 0.03 | |||
| IL 2 signaling pathway | 0.03 | |||
| TNF/Stress Related Signaling | 0.03 | |||
| Keratinocyte Differentiation | 0.03 | |||
| MAPKinase Signaling Pathway | 0.02 | |||