Table 3. Potential disease-associated proteins predicted for asthma, eczema and rhinitis.
NetZcore prediction scores are shown as z-scores. Proteins are ranked according to their average z-score for all diseases. Empty cell: the protein was not predicted to be associated with the disease with z-score > 2.31 (corresponding to P < 0.01). Exp: the protein is experimentally known to be associated to the disease. This table only shows the 30 top-scoring proteins that were found to be associated to more than one disease. The complete list is available in S12 Table.
| Protein name (UniProt accession) | gene name (HGNC) | Protein name | z-score asthma | z-score eczema | z-score rhinitis |
|---|---|---|---|---|---|
| Q9Y496 | KIF3A | kinesin family member 3A | exp | exp | 10.26 |
| P24394 | IL4R | interleukin 4 receptor | exp | 4.21 | exp |
| Q9HBE5 | IL21R | interleukin 21 receptor | exp | 3.95 | exp |
| Q9UIL8 | PHF11 | PHD finger protein 11 | exp | 2.85 | exp |
| P16278 | GLB1 | galactosidase beta 1 | 5.56 | exp | 6.03 |
| O95715 | CXCL14 | chemokine (C-X-C motif) ligand 14 | exp | 10.85 | |
| P20036 | HLA-DPA1 | major histocompatibility complex, class II, DP alpha 1 | exp | 7.93 | |
| P04440 | HLA-DPB1 | major histocompatibility complex, class II, DP beta 1 | exp | 7.81 | |
| P13500 | CCL2 | chemokine (C-C motif) ligand 2 | exp | 7 | |
| P01903 | HLA-DRA | major histocompatibility complex, class II, DR alpha | exp | 6.96 | |
| Q29974 | HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 | exp | 6.68 | |
| P01911 | HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 | exp | 6.68 | |
| P14784 | IL2RB | interleukin 2 receptor subunit beta | exp | 2.79 | 2.35 |
| P29460 | IL12B | interleukin 12B | exp | 4.3 | |
| P08887 | IL6R | interleukin 6 receptor | exp | 4.29 | |
| Q8TE73 | DNAH5 | dynein, axonemal, heavy chain 5 | exp | 3.57 | |
| P35625 | TIMP3 | TIMP metallopeptidase inhibitor 3 | exp | 2.46 | |
| P17693 | HLA-G | major histocompatibility complex, class I, G | exp | 2.37 | |
| Q9P0G3 | KLK14 | kallikrein related peptidase 14 | 12.9 | 3.78 | 18.27 |
| Q9Y337 | KLK5 | kallikrein related peptidase 5 | 9.01 | 3.64 | 12.1 |
| P14091 | CTSE | cathepsin E | 11.16 | 13.22 | |
| P53634 | CTSC | cathepsin C | 11.16 | 13.22 | |
| Q9UBX1 | CTSF | cathepsin F | 11.16 | 13.22 | |
| Q99538 | LGMN | legumain | 10.55 | 12.39 | |
| O00287 | RFXAP | regulatory factor X associated protein | 10.46 | 12.36 | |
| P10619 | CTSA | cathepsin A | 10.24 | 12.06 | |
| P43235 | CTSK | cathepsin K | 9.86 | 11.47 | |
| P52732 | KIF11 | kinesin family member 11 | 9.64 | 11.55 | |
| O15066 | KIF3B | kinesin family member 3B | 9.61 | 11.51 | |
| O14782 | KIF3C | kinesin family member 3C | 9.4 | 11.28 |