Fig. 2.

Sensory regulation of local search and dispersal behaviors. (A) osm-6 (p811) mutants exhibit dwelling-like behavior (feeding behavior) in the absence of food, with more short reversals and fewer long reversals than controls. (B) Animals with all amphid neurons killed have abnormal local search and dispersal behaviors. (C) osm-3 (p802) mutants exhibit milder defects in the absence of food. (D and E) Killing the AWC (D) or ASK (E) neurons blunts local search behavior, with fewer long reversals and omega bends at 1–6 and 7–12 min. (F) Killing ASI disrupts dispersal behavior. Killing ASI and AWC gives a mixed defect. (G–N) Killing ASH, AFD, AWB, ADL, ASJ, AWA, ASE, or ASG sensory neurons, respectively, has minor effects or no effect on feeding, local search, and dispersal behaviors. (O) tph-1 (mg280) mutants exhibit dwelling-like behavior off food, as indicated by a higher frequency of short reversals. For Figs. 2, 4, and 5, the food column refers to a 5-min interval on food, and the other columns refer to intervals after removal from food. The 1- to 6-min and 7- to 12-min intervals correspond to the local search state, and the 35- to 40-min interval corresponds to dispersal. For descriptions of short reversals or long reversals, see Fig. 1. For each data point, the circle size indicates the frequency of the behavior. Gray circles indicate controls or values not significantly different from controls. Colored circles denote statistical significance: blue, increases from control values; red, decreases from control values. The absence of a symbol indicates a value between 0 and 0.05; a red zero indicates a value in the same range that is statistically different from the control. n.d., not done. Sample sizes and P values are reported in Table 1.