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. 2005 Feb 2;102(9):3407–3412. doi: 10.1073/pnas.0409897102

Fig. 1.

Fig. 1.

Effect of time of treatment on in vivo drug response in wild-type C57BL/6J mice. (A) Survival of C57BL/6J mice after 3 × 150 mg/kg i.p. injections of CY performed at different times of the day. Animals injected at ZT10 to ZT14 demonstrate higher survival rate compared with their littermates injected at ZT22 to ZT02. (B) Dose–response curve for the survival rate of C57BL/6J mice injected at ZT14 (•) or ZT02 (○). Animals injected at ZT14 can better tolerate higher doses of the drug. (C) Total body weight loss in C57BL/6J mice after 3 × 100 mg/kg CY i.p. injections administered at ZT14 (•) or ZT02 (○). (D) Results are the same as in C after 3 × 200 mg/kg i.p. injections. At both doses, percent of body weight loss is significantly higher if injections were performed at ZT02 (at day 9, P = 0.002). Arrows indicate the days of treatment. Values represent mean ± SEM.