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. 2017 May 16;40(1):130–136. doi: 10.3892/ijmm.2017.2991

Figure 1.

Figure 1

Advanced glycation end products (AGE) induce the apoptosis of INS-1 cells. (A) TUNEL staining detected the apoptosis of INS-1 cells 48 h following exposure to AGEs (200 µg/ml). Data are presented as the means ± SEM (n=3). ***P<0.001, compared with the control group. Scale bar, 50 µm. (B) Flow cytometry was used to detect the apoptosis of INS-1 cells. INS-1 cells were exposed to 200 µg/ml AGEs for 48 h, followed by Annexin V/PI staining assay to detect the apoptosis of INS-1 cells by flow cytometry. Top left quadrant, necrotic cells; bottom left quadrant, live cells; top right quadrant, late apoptotic cells; bottom right quadrant, early apoptotic cells.