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. 2017 May 22;40(1):65–74. doi: 10.3892/ijmm.2017.2998

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Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Low expression of runt-related transcription factor 3 (RUNX3) induces angiogenesis and decreases the migration of human cardiac microvascular endothelial cells (HCMECs). (A and B) Tube formation and Transwell migration assays (Scale bars, 50 μm). (C and D) Tube formation counts and the amounts of Transwell cells (n=7, ^*P<0.05 vs. control group; ^#P<0.05 vs. hypoxia group; ^▲P<0.05 vs. RUNX3i group). (E) Western blotting of vascular endothelial growth factor receptor 1 (VEGFR1) in the HCMECs from each group. (F) Relative protein expression of VEGFR1 to GAPDH in the HCMECs from each group (n=7, ^*P<0.05 vs. control group; ^#P<0.05 vs. hypoxia group; ^▲P<0.05 vs. RUNX3i group).