Table 1.
Demographic and clinical characteristics for both analytical samples (AGES and AGESII) according survival status by 2015.
| Variables | AGES Analytical Sample (n=4,654) | AGES II Analytical Sample (n=2,653) | ||
|---|---|---|---|---|
|
|
|
|||
| Dead (n=2,108) | Alive (n=2,546) | Dead (n=683) | Alive (n=1,970) | |
|
| ||||
| Mean (SD) | ||||
| Age, yrs | 78.59 (5.52) | 74.23 (4.45) | 77.13 (5.23) | 73.79 (4.22) |
| % Weight change from age 50a | 0.91 (13.28) | 6.93 (12.10) | 2.93 (12.31) | 7.06 (11.83) |
| CAC scoreb | 955.8 (1221.5) | 473.5 (768.2) | 835.6 (1069.2) | 479.51 (791.3) |
| Creatinine, μmol/L | 96.26 (33.91) | 85.81 (20.10) | 93.53 (23.70) | 86.30 (20.20) |
| 25OHD, nmol/L | 52.33 (24.95) | 54.40 (22.80) | 53.03 (24.09) | 55.18 (22.89) |
| Proximal femur vQCT variables | ||||
| Trabecular vBMD, g/cm3 | 0.058 (0.036) | 0.066 (0.034) | 0.064 (0.036) | 0.068 (0.034) |
| Cortical vBMD, g/cm3 | 0.519 (0.040) | 0.523 (0.037) | 0.523 (0.040) | 0.525 (0.037) |
| Minimum CSA, cm2 | 10.86 (2.25) | 10.58 (2.18) | 10.90 (2.20) | 10.63 (2.14) |
| Maximum CSA, cm2 | 28.75 (4.57) | 27.70 (4.38) | 29.01 (4.52) | 27.83 (4.42) |
| % (No.) | ||||
| Female | 48.4 (1,021) | 62.4 (1,588) | 44.7 (305) | 59.9 (1,180) |
| Current smoker | 15.1 (318) | 10.3 (261) | 13.8 (94) | 9.9 (196) |
| Moderate-high PA level | 13.6 (286) | 21.1 (536) | 16.5 (113) | 22.1 (435) |
| Previous any fracture | 51.1 (1077) | 53.7 (1366) | 48.3 (330) | 53.5 (1053) |
| Poor health status | 40.1 (845) | 24.4 (620) | 69.0 (471) | 21.9 (431) |
| Impaired cognitive status | 23.9 (504) | 7.4 (188) | 12.2 (83) | 5.5 (109) |
| Diabetesc | 15.0 (316) | 9.9 (253) | 14.2 (97) | 9.3 (184) |
| Chronic lung disease | 13.0 (274) | 8.3 (211) | 13.2 (90) | 7.7 (152) |
a
Percent weight change was calculated using midlife weight data from the Reykjavik Study and baseline AGES-Reykjavik weight measurements as follows: (AGES weight – midlife weight / midlife weight) x 100.
b
A higher score indicates higher calcification,
c
Diabetes mellitus was defined as the self-reported history of diabetes, use of glucose-modifying medications or fasting blood glucose ≥ 7.0 mmol/l.
CAC= coronary artery calcium, CSA= cross-sectional area, PA= physical activity, vQCT= volumetric quantitative computed tomographic, vBMD= volumetric bone mineral density.