Table 2.

Associations of proximal femur trabecular and cortical vBMD (by lowest versus the highest three quartiles of vBMD) with mortality in participants from the AGES-Reykjavik Study, 2002–2006 (n= 4,654).

QCT Proximal femur vBMD	AGES analytical sample (no. of deaths = 2,108)
	Model	HR	95% CI
Trabecular (Q1 <0.037 g/cm3)	1	1.21	1.09, 1.35
	2	1.20	1.08, 1.34
	3	1.12	1.01, 1.25
	4	1.07	0.96, 1.19
Cortical (Q1 <0.496 g/cm3)	1	1.06	0.96, 1.18
	2	1.10	0.99, 1.22
	3	1.08	0.97, 1.20
	4	1.05	0.94, 1.16

Trabecular and cortical variables were included together in all COX models. Bolded values are significant.

Model 1 is adjusted for sex, age, proximal femur minimum cross-sectional area (femoral neck) and maximum cross-sectional area; Model 2 is adjusted for all of the factors in model 1 plus health variables including baseline history of diabetes and chronic lung disease, coronary artery calcium score, Creatinine, cognitive status and self-reported health status; Model 3 is additionally adjusted for lifestyle factors including 25OHD, smoking status, physical activity level, weight change from age 50, and self-reported history of previous fracture. Model 4 is additionally adjusted for fracture status as a time-varying covariate.