Table 3.

Adjusted HRs of mortality by quartile of bone change (faster rate of bone loss versus the other three quartiles of the annual percent change in bone) in participants from the AGES II, 2007–2011 (n= 2,653).

QCT Proximal femur bone loss,	AGES II analytical sample (no. of deaths = 683)
	Model	HR	95% CI
Trabecular (Q1≥-2.25 %/year)	1	1.48	1.25, 1.76
	2	1.48	1.24, 1.76
	3	1.37	1.15, 1.64
	4	1.32	1.11, 1.58
Cortical (Q1≥-0.13 %/year)	1	1.41	1.20, 1.66
	2	1.37	1.16, 1.61
	3	1.33	1.13, 1.57
	4	1.34	1.14, 1.58

Trabecular and cortical variables were included together in all COX models. Bolded values are significant.

Model 1 is adjusted for sex, age, proximal femur minimum cross-sectional area (femoral neck) and maximum cross-sectional area; Model 2 is adjusted for all of the factors in model 1 plus health variables including baseline history of diabetes and chronic lung disease, coronary artery calcium score, Creatinine, cognitive status and self-reported health status; Model 3 is additionally adjusted for lifestyle factors including 25OHD, smoking status, physical activity level, weight change from age 50, and self-reported previous fracture; Model 4 is similar to model 3 but is additionally adjusted for fracture status as a time-varying covariate.