Table 1a.
General characteristics of subjects with femoral neck BMD information available in RS-I, RS-II and RS-III according to quintiles of fasting phosphate levels
| Men | Women | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Phosphate in quintiles | Phosphate in quintiles | |||||||||||
| 1 | 2 | 3 | 4 | 5 | p* | 1 | 2 | 3 | 4 | 5 | p* | |
| I) RS-I | ||||||||||||
| N Phosphate Mean (mg/dL) |
242 (2.56) | 243 (2.92) | 243 (3.14) | 243 (3.37) | 243 (3.76) | 322 (3.02) | 322 (3.40) | 322 (3.62) | 322 (3.84) | 322 (4.22) | ||
| Range (mg/dL) | 1.9–2.8 | 2.8–3.0 | 3.0–3.3 | 3.3–3.5 | 3.5–4.9 | 2.3–3.3 | 3.3–3.5 | 3.5–3.7 | 3.7–3.9 | 3.9–5.1 | ||
| Age (y) | 71.9 | 72.3 | 71.7 | 72.3 | 71.9 | 0.982 | 72.8 | 72.2 | 72.9 | 72.1 | 72.3 | 0.297 |
| BMI (kg/m2) | 26.6 | 26.5 | 26.4 | 26.1 | 26.1 | 0.020 | 28.7 | 27.7 | 27.2 | 26.6 | 25.8 | <0.001 |
| Smoke (%) | 87% | 87% | 93% | 92% | 94% | 0.002 | 47% | 49% | 52% | 52% | 48% | 0.615 |
| Calcium (mg/dL) | 9.58 | 9.66 | 9.62 | 9.64 | 9.72 | 0.001 | 9.77 | 9.79 | 9.77 | 9.80 | 9.86 | 0.006 |
| 25OHD (nmol/L) | 63.4 | 61.7 | 60.5 | 58.3 | 59.1 | 0.013 | 47.2 | 47.7 | 45.9 | 49.7 | 50.5 | 0.057 |
| FN-BMD (g/cm2) | 0.90 | 0.90 | 0.91 | 0.90 | 0.88 | 0.124 | 0.82 | 0.80 | 0.79 | 0.79 | 0.78 | <0.001 |
| Glucose (mmol/L) | 6.07 | 6.01 | 5.99 | 5.99 | 6.16 | 0.593 | 6.13 | 5.83 | 5.93 | 5.72 | 5.76 | 0.001 |
| Prevalent DM (%) | 12% | 14% | 13% | 9% | 15% | 0.623 | 16% | 10% | 12% | 8% | 9% | 0.003 |
| Creatinine (mg/dL) | 1.04 | 1.05 | 1.02 | 1.03 | 1.06 | 0.548 | 0.82 | 0.82 | 0.82 | 0.81 | 0.82 | 0.977 |
| eGFR (mL/min) | 73.5 | 72.3 | 74.7 | 73.9 | 73.3 | 0.676 | 73.2 | 73.5 | 73.5 | 74.2 | 73.9 | 0.632 |
| Na+ (mmol/L) | 142.3 | 142.1 | 142.4 | 141.8 | 142.1 | 0.218 | 142.3 | 142.5 | 142.7 | 142.3 | 142.5 | 0.957 |
| K+ (mmol/L) | 4.32 | 4.41 | 4.45 | 4.43 | 4.53 | <0.001 | 4.30 | 4.37 | 4.44 | 4.43 | 4.49 | <0.001 |
| II) RS-II | ||||||||||||
| N Phosphate Mean (mg/dL) |
181 (2.48) | 182 (2.84) | 182 (3.06) | 182 (3.29) | 182 (3.70) | 209 (2.91) | 209 (3.31) | 210 (3.52) | 209 (3.76) | 210 (4.14) | ||
| Range (mg/dL) | 1.4–2.7 | 2.7–2.9 | 2.9–3.2 | 3.2–3.4 | 3.4–4.7 | 1.8–3.2 | 3.2–3.4 | 3.4–3.6 | 3.6–3.9 | 3.9–5.1 | ||
| Age (y) | 63.4 | 64.1 | 64.5 | 63.5 | 63.2 | 0.555 | 64.2 | 64.5 | 63.4 | 63.8 | 62.2 | 0.002 |
| BMI (kg/m2) | 27.2 | 26.7 | 26.7 | 26.8 | 27.1 | 0.791 | 28.8 | 27.7 | 27.4 | 26.5 | 26.1 | <0.001 |
| Smoke (%) | 87% | 78% | 82% | 88% | 89% | 0.052 | 57% | 63% | 60% | 57% | 63% | 0.690 |
| Calcium (mg/dL) | 9.52 | 9.58 | 9.54 | 9.57 | 9.62 | 0.014 | 9.64 | 9.65 | 9.69 | 9.68 | 9.74 | 0.005 |
| 25OHD (nmol/L) | 65.5 | 68.5 | 66.3 | 65.7 | 63.8 | 0.355 | 59.0 | 56.8 | 59.6 | 58.2 | 63.4 | 0.294 |
| FN-BMD (g/cm2) | 0.98 | 0.98 | 0.95 | 0.98 | 0.97 | 0.478 | 0.89 | 0.88 | 0.91 | 0.88 | 0.87 | <0.001 |
| Glucose (mmol/L) | 6.06 | 5.98 | 6.17 | 5.89 | 6.49 | 0.041 | 6.13 | 5.81 | 5.77 | 5.83 | 5.87 | 0.194 |
| Prevalent DM (%) | 12% | 9% | 15% | 11% | 20% | 0.024 | 13% | 8% | 10% | 10% | 9% | 0.450 |
| Creatinine (mg/dL) | 0.98 | 0.99 | 0.99 | 0.98 | 0.99 | 0.571 | 0.78 | 0.77 | 0.79 | 0.77 | 0.78 | 0.640 |
| eGFR (mL/min) | 81.8 | 81.3 | 80.2 | 81.9 | 82.4 | 0.714 | 80.8 | 81.7 | 80.4 | 82.3 | 82.4 | 0.843 |
| Na+ (mmol/L) | 140.9 | 141.1 | 141.2 | 141.1 | 141.1 | 0.318 | 141.2 | 141.4 | 141.5 | 141.6 | 141.7 | 0.032 |
| K+ (mmol/L) | 4.16 | 4.21 | 4.21 | 4.27 | 4.26 | <0.001 | 4.17 | 4.23 | 4.24 | 4.25 | 4.28 | <0.001 |
| III) RS-III | ||||||||||||
| N Phosphate Mean (mg/dL) |
174 (2.56) | 174 (2.94) | 174 (3.20) | 174 (3.45) | 174 (3.87) | 228 (2.97) | 228 (3.39) | 228 (3.63) | 228 (3.85) | 229 (4.26) | ||
| Range (mg/dL) | 1.6–2.8 | 2.8–3.0 | 3.0–3.3 | 3.3–3.6 | 3.6–5.4 | 2.1–3.2 | 3.2–3.5 | 3.5–3.7 | 3.7–3.9 | 3.9–5.1 | ||
| Age (y) | 57.4 | 57.6 | 57.4 | 56.6 | 55.8 | 0.008 | 56.2 | 57.5 | 57.2 | 57.6 | 56.8 | 0.304 |
| BMI (kg/m2) | 28.2 | 28.2 | 27.6 | 27.4 | 27.4 | 0.017 | 29.2 | 27.9 | 27.1 | 27.1 | 26.9 | <0.001 |
| Smoke (%) | 77% | 74% | 83% | 76% | 72% | 0.640 | 64% | 67% | 69% | 60% | 69% | 0.720 |
| Calcium (mg/dL) | 9.68 | 9.79 | 9.82 | 9.87 | 9.88 | <0.001 | 9.74 | 9.78 | 9.85 | 9.90 | 10.0 | <0.001 |
| 25OHD (nmol/L) | 57.5 | 60.0 | 59.1 | 63.1 | 63.4 | 0.011 | 56.3 | 58.1 | 62.3 | 59.9 | 62.3 | 0.014 |
| FN-BMD (g/cm2) | 0.98 | 0.99 | 0.99 | 1.00 | 0.98 | 0.902 | 0.93 | 0.92 | 0.92 | 0.91 | 0.92 | 0.701 |
| Glucose (mmol/L) | 5.92 | 5.71 | 5.74 | 5.78 | 5.92 | 0.661 | 5.40 | 5.50 | 5.38 | 5.41 | 5.72 | 0.346 |
| Prevalent DM (%) | 12% | 8% | 10% | 12% | 14% | 0.364 | 5% | 7% | 4% | 6% | 5% | 0.764 |
| Creatinine (mg/dL) | 0.94 | 0.97 | 0.99 | 0.97 | 0.97 | 0.140 | 0.78 | 0.77 | 0.77 | 0.77 | 0.78 | 0.671 |
| eGFR (mL/min) | 88.0 | 85.7 | 85.9 | 86.5 | 88.2 | 0.391 | 85.4 | 86.0 | 86.2 | 85.6 | 85.5 | 0.664 |
| Na+ (mmol/L) | 141.6 | 141.9 | 142.1 | 142.3 | 142.3 | 0.017 | 141.8 | 142.0 | 142.2 | 142.0 | 142.9 | <0.001 |
| K+ (mmol/L) | 4.29 | 4.39 | 4.42 | 4.41 | 4.45 | <0.001 | 4.30 | 4.33 | 4.38 | 4.38 | 4.44 | <0.001 |
*
P values corresponds to age-adjusted significance of trend across quintiles. BMI: body mass index. Smoke: ever smoke. 25OHD: 25-hydroxyvitamin D levels; FN-BMD: femoral neck bone mineral density; prevalent DM: prevalent diabetes mellitus; creatin: creatinine; eGFR: estimated glomerular filtration rate according to Chronic Kidney Disease Epidemiology Collaboration equations based on creatinine levels. Conversion to SI Units: to convert 25-hydroxyvitamin D levels to ng/mL multiply by 0.4; to convert glucose to mg/dL multiply by 18.02