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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Eur J Pain. 2017 Feb 3;21(6):1039–1050. doi: 10.1002/ejp.1002

Figure 2.

Figure 2

The analgesic effects of KOPr agonists in the hot water tail-withdrawal assay in mice. The maximal possible effect (%MPE ± SEM) at each time point was calculated as a percent based on pre-treatment control latencies. Values shown in brackets represent dose in mg/kg. Mice were treated with the KOPr agonists (a) ICI 204,448, (b) SalA and (c) β-THP SalB. Analysed using two-way repeated measures ANOVA followed by Bonferroni post-test. (d) Non-linear regression analysis showing dose-response effect of KOPr agonists. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001 for 2 mg/kg doses compared to vehicle. #p<0.05, ##p<0.01, ###p<0.001, ####p<0.0001 for 1 mg/kg doses compared to vehicle. ^p<0.05 and ^^^^p<0.001 for comparison between the two dosages. (n=6–12 per group).