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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: J Orthop Res. 2017 Jan 15;35(9):1876–1885. doi: 10.1002/jor.23502

Figure 2. ACL injury induces increased connective tissue fibroblast abundance in skeletal muscle.

Figure 2

(A–B) Representative immunohistochemical images demonstrating Tcf4+ connective tissue fibroblasts (white arrowheads, red), muscle connective tissue (green), and DAPI (blue) in the non-injured (A) and injured (B) limb skeletal muscle. Scale bar = 50µm. (C) Quantification of Tcf4+ fibroblasts presented as mean number of fibroblasts per muscle area (mm2) ± SEM. (D) Correlation of the number of fibroblasts per mm2 with percent area of muscle connective tissue in the injured limb. N = 10 subjects. NI = non-injured; I = injured. * Significantly different from the non-injured limb (p < 0.05).