Skip to main content
. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Photochem Photobiol. 2017 Jan 27;93(4):943–955. doi: 10.1111/php.12691

Figure 3. Autophagy in UVA response.

Figure 3

UVA-induced ROS production stimulates autophagy, and autophagy regulates the oxidative stress response following UVA. UVA stabilizes p53, which induces transcription of autophagy activators AMPK and Sesn2. Conversely, UVA suppresses PTEN expression, which may negatively impact autophagy induction following UVA. Autophagy clears oxidized proteins and lipids following UVA exposure, but suppresses Nrf2-mediated antioxidant response following UVA.