Figure 1.

Structure of stilbene analogues (A) resveratrol and (B) isorhapontigenin. Effects of stilbene analogues on the release of cytokines stimulated by 1 ng·mL⁻¹ IL‐1β + 50% CSE in primary human airway epithelial cells. Primary cells from both (C, E) healthy and (D, F) COPD patients were treated with various concentrations of either resveratrol or isorhapontigenin for 1 h before stimulation with 1 ng·mL⁻¹ IL‐1β + 50% CSE for 24 h. Cell media were harvested and (C, D) IL‐6 and (E, F) CXCL8 measured by elisa (n = 5). Differences in response between cells from healthy subjects and COPD patients were analysed using Mann–Whitney U‐tests but were not significant.