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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Cell Calcium. 2016 Dec 30;63:33–39. doi: 10.1016/j.ceca.2016.12.009

Figure 1. Proposed model for TRPC1 activation.

Figure 1

Following store depletion, STIM1 aggregates and translocates to the ER-PM junction. Orai1 is recruited to the STIM1 puncta resulting in CRAC channel activation. The resulting [Ca2+]i increase leads to NFAT activation and insertion of TRPC1-containing vesicles into the plasma membrane (Modified from [55]). Insets in the figure show I-V relationships of the currents recorded under the various conditions; ICRAC generated by Orai1+STIM1 (left) and ISOC generated by combination of TRPC1+STIM1 and Orai1+STIM1 channels.