Figure 2.

The use of computational techniques to identify novel therapeutic targets in adult zebrafish. Testing psychoactive compounds across various strains and transgenic lines of zebrafish in a wide range of behavioural and cognitive tasks can be used to generate a data library. Computational tools, such as hierarchical modelling and similarity ensemble approach (SEA), can help identify target hits, enabling the predictions about the effects of various drug combinations. The hypotheses generated may then be tested in vivo using larval or adult animals.