Table 1.
Hemodynamic parameters
| Time (h) | 0 | 1.25 | 1.5 | 1.6 | 2.5 | 3.5 | 4.5 | 5.5 | 6.5 | 7.5 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | ||
| Cardiac output (L/min) | Vehicle | 8.4 | 0.6 | 7.7 | 0.4 | 7.7 | 0.5 | 7.9 | 0.6 | 7.6 | 1.3 | 9.0 | 0.4 | 8.6 | 0.3 | 8.5 | 0.2 | 8.3 | 0.3 | 7.8 | 0.3 |
| PDNO | 7.2 | 0.3 | 6.5 | 0.6 | 6.6 | 0.5 | 6.5 | 0.4 | 8.1 | 0.7 | 8.5 | 0.5 | 8.3 | 0.3 | 8.2 | 0.4 | 8.3 | 0.5 | 7.7 | 0.4 | |
| Heart rate (BPM) | Vehicle | 110 | 4 | 103 | 5 | 106 | 5 | 107 | 4 | 109 | 3 | 113 | 2 | 107 | 3 | 109 | 4 | 108 | 4 | 102 | 3 |
| PDNO | 108 | 3 | 95 | 8 | 111 | 4 | 114 | 5 | 116 | 5 | 115 | 3 | 109 | 2 | 109 | 5 | 112 | 3 | 108 | 3 | |
| Mean arterial blood pressure (mmHg) | Vehicle | 100 | 2 | 107 | 5 | 102 | 4 | 100 | 4 | 96 | 4 | 96 | 4 | 95 | 3 | 93 | 3 | 93 | 4 | 94 | 3 |
| PDNO | 95 | 3 | 104 | 6 | 88 | 4 | 82 | 3 | 85 | 2 | 83 | 2 | 82 | 2 | 82 | 2 | 81 | 2 | 83* | 3 | |
Cardiovascular data from 16 anesthetized sheep subjected to left renal ischemia and reperfusion. Renal ischemia was caused by clamping of the left renal artery for 90 min. Fifteen minutes prior to the release of the clamp, intravenous infusions of either the organic mononitrites of 1,2-propanediol (PDNO, n = 8) or vehicle (propanediol + inorganic nitrite, n = 8) was commenced. The infusions continued for 6 h. Data are expressed as mean and SEM.
*Significant (p < 0.05) differences in response to PDNO compared to vehicle at the end of the infusion