Linezolid long-term effects. A) Global nDNA methylation of untreated (dashed line) or 30 and 90 μM linezolid (L30 and L90)-treated human adipose tissue-derived stem cells (hASCs). B) Mitochondrial enzymes. CSsa, CIVsa and CIVq code for citrate synthase and respiratory complex IV specific activities and respiratory complex IV quantity, respectively. C) Parameters of adipocyte differentiation. Dashed line (100%), in B and C, represents the mean values for LIN-untreated adipocyte differentiated hASCs. The bars indicate the percentage in adipocyte-differentiated hASCs previously treated with linezolid 30 μM. Error bars represent the standard deviation. *, P = 0.0194 (versus untreated hASCs). #, P = 0.048 (versus 30 μM linezolid-treated hASCs). &, P ≤ 0.0367 (versus LIN-untreated adipocyte differentiated hASCs).